Structure of PDB 7xzy Chain A Binding Site BS01

Receptor Information
>7xzy Chain A (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSS
AVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>7xzy Chain I (length=165) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgagccaggcctgagaatccggtgccgaggccgctcaattggtcgtagac
agctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaac
cgccaaggggattactccctagtctccaggcacgtgtcagatatagggca
tgtccgggcatgtcc
Receptor-Ligand Complex Structure
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PDB7xzy Structural basis for p53 binding to its nucleosomal target DNA sequence.
Resolution3.97 Å
Binding residue
(original residue number in PDB)		R42 R72 R83 F84 Q85 K115 R116 V117 K122
Binding residue
(residue number reindexed from 1)		R5 R35 R46 F47 Q48 K78 R79 V80 K85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0010467 gene expression
GO:0032200 telomere organization
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xzy, PDBe:7xzy, PDBj:7xzy
PDBsum7xzy
PubMed36714865
UniProtP68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)

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