Structure of PDB 7xyd Chain A Binding Site BS01

Receptor Information
>7xyd Chain A (length=129) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIECDSCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGDI
YKKLYHSDACSSKAVVSLRCIACGVNLND
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7xyd Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7xyd Crystal structure of TMPRSS2 in complex with Nafamostat
Resolution2.58 Å
Binding residue
(original residue number in PDB)		N131 D134 V136 H138 D144 E145
Binding residue
(residue number reindexed from 1)		N12 D15 V17 H19 D25 E26
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.122: transmembrane protease serine 2.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7xyd, PDBe:7xyd, PDBj:7xyd
PDBsum7xyd
PubMed37990007
UniProtO15393|TMPS2_HUMAN Transmembrane protease serine 2 (Gene Name=TMPRSS2)

[Back to BioLiP]