Structure of PDB 7xu8 Chain A Binding Site BS01

Receptor Information
>7xu8 Chain A (length=166) Species: 9838 (Camelus dromedarius) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGSIVPRREWRALASECRERLTRPVRYVVVSHTAGSHCDTPASCAQQAQN
VQSYHVRNLGWCDVGYNFLIGEDGLVYEGRGWNIKGAHAGPTWNPISIGI
SFMGNYMNRVPPPRALRAAQNLLACGVALGALRSNYEVKGHRDVQPTLSP
GDRLYEIIQTWSHYRA
Ligand information
Ligand IDPEO
InChIInChI=1S/H2O2/c1-2/h1-2H
InChIKeyMHAJPDPJQMAIIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
CACTVS 3.385
OpenEye OEToolkits 2.0.7		OO
FormulaH2 O2
NameHYDROGEN PEROXIDE
ChEMBLCHEMBL71595
DrugBankDB11091
ZINC
PDB chain7xu8 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7xu8 Ligand recognition by peptidoglycan recognition protein-S (PGRP-S): structure of the complex of camel PGRP-S with heptanoic acid at 2.15 angstrom resolution.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		S167 R170
Binding residue
(residue number reindexed from 1)		S162 R165
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan immune receptor activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0009253 peptidoglycan catabolic process
GO:0016045 detection of bacterium
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:7xu8, PDBe:7xu8, PDBj:7xu8
PDBsum7xu8
PubMed36188729
UniProtQ9GK12|PGRP1_CAMDR Peptidoglycan recognition protein 1 (Gene Name=PGLYRP1)

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