Structure of PDB 7xna Chain A Binding Site BS01

Receptor Information

>7xna Chain A (length=472) Species: 1397,9606

TSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIANE
LFMLGLPFLAMQVALEHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDR
YLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGR
SSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSAST
DYWQNWTFGGGIVNAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINY
NAGVWAPNGNGYLTLYGWTRSPLIEYYVVDSWGTYRPTGTYKGTVKSDGG
TYDIYTTTRYNAPSIDGDDTTFTQYWSVRQSKRPTGSNATITFTNHVNAW
KSHGMNLGSNWAYQVMATEGYQSSGSSNVTVWSSKRKKSEKKVTRMVSIV
VAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPIL
YAFLDDNFKKSFQNVLCLVKVS

Ligand information

>7xna Chain B (length=8) Species: 32630 (synthetic construct)

FCYWKTCY

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7xna Structural insights into ligand recognition and selectivity of somatostatin receptors.
• Resolution: 2.65 Å
• Binding residue (original residue number in PDB): N43 E106 M119 D122 Q126 T194 Y205 F275 M282 P286 L290 K291 F294 D295 V298
• Binding residue (residue number reindexed from 1): N3 E66 M79 D82 Q86 T154 Y165 F414 M421 P425 L429 K430 F433 D434 V437

Enzymatic activity

• Enzyme Commision number: 3.2.1.8: endo-1,4-beta-xylanase.

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0004930 G protein-coupled receptor activity
• GO:0004994 somatostatin receptor activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0031176 endo-1,4-beta-xylanase activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0045493 xylan catabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7xna, PDBe:7xna, PDBj:7xna
• PDBsum: 7xna
• PubMed: 35739238
• UniProt: P09850|XYNA_NIACI Endo-1,4-beta-xylanase (Gene Name=xlnA);
  P30874|SSR2_HUMAN Somatostatin receptor type 2 (Gene Name=SSTR2)