Structure of PDB 7xav Chain A Binding Site BS01

Receptor Information
>7xav Chain A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADEL
FMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRY
LAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRS
SCTINWPWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSK
RKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDF
VVVLTYANSCANPILYAFLSDNFKKSFQNV
Ligand information
Receptor-Ligand Complex Structure
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PDB7xav Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues.
Resolution2.87 Å
Binding residue
(original residue number in PDB)		T194 Y205 F208 T212 F272 S279 F294
Binding residue
(residue number reindexed from 1)		T153 Y159 F162 T166 F226 S233 F248
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004994 somatostatin receptor activity
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0042923 neuropeptide binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell population proliferation
GO:0021549 cerebellum development
GO:0030432 peristalsis
GO:0030900 forebrain development
GO:0038170 somatostatin signaling pathway
GO:0042594 response to starvation
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071392 cellular response to estradiol stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xav, PDBe:7xav, PDBj:7xav
PDBsum7xav
PubMed35595746
UniProtP30874|SSR2_HUMAN Somatostatin receptor type 2 (Gene Name=SSTR2)

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