Structure of PDB 7xa7 Chain A Binding Site BS01

Receptor Information
>7xa7 Chain A (length=596) Species: 59477 (Rhinolophus affinis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STTEDRAKIFLDNFNREAEELSYQSSLASWEYNTNISDENVQKMDEAGAK
WSAFYEEQSKLAKNYPLEEIQTVPVKLQLQILQQSGSPVLSEDKSKRLNS
ILNAMSTIYSTGKVCKPNNPQECFLLEPGLDNIMGTSKDYNERLWAWEGW
RAEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESSGSGYS
RDQLMKDVDRIFTEIKPLYEHLHAYVRTKLMDTYPFHISPTGCLPAHLLG
DMWGRFWTNLYPLTVPFGQKPNIDVTDAMVNQGWDANRIFKEAEKFFVSV
GLPNMTEGFWNNSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMED
FLTAHHEMGHIQYDMAYATQPYLLRNGANEGFHEAVGEVMSLSVATPKHL
KTMGLLSPDFLEDNETEINFLLKQALNIVGTLPFTYMLEKWRWMVFRGEI
PKEEWMKKWWEMKRDLVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTR
TIFEFQFHEALCRIAQHDGPLHKCDISNSTDAGKKLHQMLSVGKSQPWTV
TLKDIVDSRNMDVGPLLRYFEPLYTWLQEQNRKSYVGWNTDWSPYS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7xa7 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7xa7 Structural basis of SARS-CoV-2 and its variants binding to intermediate horseshoe bat ACE2.
Resolution3.31 Å
Binding residue
(original residue number in PDB)		H357 H361 E385
Binding residue
(residue number reindexed from 1)		H356 H360 E384
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xa7, PDBe:7xa7, PDBj:7xa7
PDBsum7xa7
PubMed35874946
UniProtA0A7D7FA76

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