Structure of PDB 7x8a Chain A Binding Site BS01

Receptor Information
>7x8a Chain A (length=1266) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAG
KSFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSF
LRKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFS
NFDLDHKQEKNDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGT
YTGRITLRNEHAKKLLLASLGFVDKLCGALCRIEVIHNDELRKQAEVIVE
AFKQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDI
KVQGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGGVSTRFR
ILGDTEYYSKAHDSEGSDLFIPVTPPEGIETKEWIIVGRLKAATPFYFGV
QQPSDSIPGKEKKSEDSLVINEHTSFNILLDKENRYRIPRSALRGALRRD
LRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVSDFSEPPEIRYRIA
KNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFPEQLSSVIRYWEEN
DGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKINEYIKERGMRGKEK
ELLEMGESSLPDGLIPYKFFEERECLFPYKENLKPQWSEVQYTIEVGSPL
LTADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPRFAVKSETHRGIFR
TAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLELINGNEFEK
LEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGRFWIKKGFSG
DHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVPDDFKEMING
PINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDIITHEEFTE
ELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNINGELM
IPGSELRGMLRTHFEALTKSCFAIFGEDSTLSKTLGGKLDKALHPCTGLS
DGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERSLTLGVLE
SPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPERNVTTE
VMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGKPYGFGSV
KIKIDSLHTFKINSNNDKIKRVPQSDIREYINKGYQKLIEWSGVLPQWHV
IPHIDKLYKLLWVPFLNDSKLEPDVRYPVLNEESKGDYTYKKLGDKDNLP
YKTRVKGLTTPWSPWN
Ligand information
>7x8a Chain C (length=33) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacuuaaugucacgguacccaauuuucugcccc
.................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x8a Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E16 W23 R37 Q39 F41 T45 K47 K55 F57 G60 T61 L62 R64 S65 S91 F92 Q93 T94 K101 P102 S103 F104 L105 R106 K107 R108 L133 G134 R135 G140 K141 E144 Y149 H152 F153 S154 N155 D157 I177 L178 N179 R180 V181 G186 K187 A188 D190 Y191 F192 G232 R380 Y389 S391 G431 R472 S473 A474 R476 G477 R481 S494 L495 G496 G497 L500 T513 L514 Y529 R530 I531 A532 K533 V540 L545 F546 G593 S596 T684 A685 K723 T726 R728 G729 I730 T733 G759 N760 E761 S764 S765 D788 H789 V790 A791 I792 R794 G798 A799 D801 K804 F805 S854 K855 Y922 P967 T969 S1001 E1002 R1004 R1008 I1021 G1421 T1422 T1423 Y1425 K1426 V1458 L1459 E1460 S1461 P1462 R1463 K1479 Y1481 K1551 G1552 K1553 P1554 Y1645 L1648 Y1663
Binding residue
(residue number reindexed from 1)		E12 W19 R33 Q35 F37 T41 K43 K51 F53 G56 T57 L58 R60 S61 S87 F88 Q89 T90 K97 P98 S99 F100 L101 R102 K103 R104 L129 G130 R131 G136 K137 E140 Y145 H148 F149 S150 N151 D153 I173 L174 N175 R176 V177 G182 K183 A184 D186 Y187 F188 G228 R348 Y357 S359 G399 R440 S441 A442 R444 G445 R449 S462 L463 G464 G465 L468 T481 L482 Y497 R498 I499 A500 K501 V508 L513 F514 G561 S564 T652 A653 K691 T694 R696 G697 I698 T701 G727 N728 E729 S732 S733 D756 H757 V758 A759 I760 R762 G766 A767 D769 K772 F773 S822 K823 Y875 P920 T922 S954 E955 R957 R961 I974 G1011 T1012 T1013 Y1015 K1016 V1048 L1049 E1050 S1051 P1052 R1053 K1069 Y1071 K1141 G1142 K1143 P1144 Y1227 L1230 Y1240
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:7x8a, PDBe:7x8a, PDBj:7x8a
PDBsum7x8a
PubMed36302881
UniProtA0A0B0EGF3

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