Structure of PDB 7x7r Chain A Binding Site BS01

Receptor Information
>7x7r Chain A (length=1237) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAG
KSFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSF
LRKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFS
NFDLDHKQEKNDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGT
YTGRITLRNEHAKKLLLASLGFVDKLCGALCRIEVIHNDELRKQAEVIVE
AFKQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDI
KVQGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGDTEYYSK
AHDSEGSDLFIPVTPPEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGK
EKEHASFNILLDKENRYRIPRSALRGALRRDLRTAFGSGCNVSLGGQILC
NCKVCIEMRRITLKDSVSDFSEPPEIRYRIAKNPGTATVEDGSLFDIEVG
PEGLTFPFVLRYRGHKFPEQLSSVIRYWEENDGKNGMAWLGGLDSTGKGR
FALKDIKIFEWDLNQKINEYIKERGMRGKEKELLEMGESSLPDGLIPYKF
FEERECLFPYKENLKPQWSEVQYTIEVGSPLLTADTISALTEPGNRAAIA
YKKRVYNDGNNAIEPEPRFAVKSETHRGIFRTAVGRRTGDLGKEDHEDCT
CDMCIIFGNEHESSKIRFEDLELINGNEFEKLEKHIDHVAIDRFTGGALD
KAKFDTYPLAGSPKKPLKLKGRFWIKKGFSGDHKLLITTALSDIRDGLYP
LGSKGGVGYGWVAGISIDDNVPDDFKEMINGPINNDYVHPGHQSPKIYYP
HYFLDSGSKVYREKDIITHEEFTEELLSGKINCKLETLTPLIIPDTSDEN
GLKLQGNKPGHKNYKFFNINGELMIPGSELRGMLRTHFEALTKSCFAIFG
EDSTLSKTLGGKLDKALHPCTGLSDGLCPGCHLFGTTDYKGRVKFGFAKY
ENGPEWLITRGNNPERSLTLGVLESPRPAFSIPDDESEIPGRKFYLHHNG
WRIIRQKQLEIRETVQPERNVTTEVMDKGNVFSFDVRFENLREWELGLLL
QSLDPGKNIAHKLGKGKPYGFGSVKIKIDSLHTFKINSNNDKIKRVPQSD
IREYINKGYQKLIEWVLPQWHVIPHIDKLYKLLWVPFLLEPDVRYPVLNE
ESKGYIEDYTYKKLGDKDNLPYKTRVKGLTTPWSPWN
Ligand information
>7x7r Chain C (length=36) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggacuuaaugucacgguacccaauuuucugccccgg
....................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x7r Structure and function of a bacterial type III-E CRISPR-Cas7-11 complex.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		W23 R37 Q39 F41 T45 F57 G60 T61 R64 S65 S91 F92 Q93 T94 E96 P102 F104 L105 R106 K107 L133 G134 R135 D137 K141 Y149 H152 F153 S154 N155 R176 I177 L178 N179 R180 V181 G186 K187 A188 D190 Y191 F192 R208 K229 Y389 G431 V432 R472 S473 A474 R476 R480 V493 S494 L495 G496 G497 L500 M509 R510 T513 L514 Y529 R530 I531 K533 V540 L545 F546 G593 L594 D595 S596 T684 A685 K723 T726 R728 G729 I730 R732 T733 S765 D788 H789 V790 A791 I792 R794 G797 A799 K804 F805 S854 G857 Y922 H924 P967 T969 S1001 E1002 R1004 G1005 R1008 I1021 G1421 T1422 T1423 D1424 K1426 L1459 E1460 S1461 P1462 R1463 F1466 K1479 K1551 G1552 K1553 Y1645 Y1663
Binding residue
(residue number reindexed from 1)		W19 R33 Q35 F37 T41 F53 G56 T57 R60 S61 S87 F88 Q89 T90 E92 P98 F100 L101 R102 K103 L129 G130 R131 D133 K137 Y145 H148 F149 S150 N151 R172 I173 L174 N175 R176 V177 G182 K183 A184 D186 Y187 F188 R204 K225 Y347 G389 V390 R421 S422 A423 R425 R429 V442 S443 L444 G445 G446 L449 M458 R459 T462 L463 Y478 R479 I480 K482 V489 L494 F495 G542 L543 D544 S545 T633 A634 K672 T675 R677 G678 I679 R681 T682 S714 D737 H738 V739 A740 I741 R743 G746 A748 K753 F754 S803 G806 Y849 H851 P894 T896 S928 E929 R931 G932 R935 I948 G985 T986 T987 D988 K990 L1023 E1024 S1025 P1026 R1027 F1030 K1043 K1115 G1116 K1117 Y1195 Y1211
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7x7r, PDBe:7x7r, PDBj:7x7r
PDBsum7x7r
PubMed36302881
UniProtA0A0B0EGF3

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