Structure of PDB 7x6s Chain A Binding Site BS01

Receptor Information
>7x6s Chain A (length=1453) Species: 11624 (Lymphocytic choriomeningitis virus (strain Armstrong)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDEIISELRELCLNYIEQDERLSRQKLNFLGQREPRMVLIEGLKLLSRCI
EIDSADKSGCTHNHDDKSVETILVESGIVCPGLPLIIPDGYKLIDNSLIL
LECFVRSTPASFEKKFIEDTNKLACIREDLAVAGVTLVPIVDGRCDYDNS
FMPEWANFKFRDLLFKLLEYSNQNEKVFEESEYFRLCESLMDSMKILKDA
RSTHNDEIMRMCHEGINPNMSCDDVVFGINSLFSRFRRDLESGKLKRNFQ
KVNPEGLIKEFSELYENLADSDDILTLSREAVESCPLMRFITAETHGTEY
ERLLSMLNKVKSLKLLNTRRRQLLNLDVLCLSSLIKQSCYSSVNDRLVSF
HSTKEEFIRLLRNRKKSKVRASISEFIAKIQKCLLVVGLSFEHYGLSEHL
EQECHIPFTEFENFMKIGAHPIMYYNFQPSTEQLKNIQSLRRLSSVCLAL
TNSMKTSSVCKEVFCQVIKLDSEEYHLLYQKTGESSRCYSIQGPDGHLIS
FYADPKRFFLPIFSDEVLYNMIDIMISWIRSCPDLKDCLTDIEVALRTLL
LLMLTNPTKRNQKQVQSVRYLVMAIVSDFSSTSLMDKLREDLITPAEKVV
YKLLRFLIKTIFGTGEKVLLSAKFKFMLNVSYLCHLITKETPDRLTDQIK
CFEKFFEPKSQFGFFVNPKEAITPEEECVFYEQMKRFTSKEIDCQHTTPG
VNLEAFSLMVSSFNNGTLIFLLVSAVSQITESFVRKYEYKVSKLVSRLVI
GSKGEETGRSEDCFDGEEETSFFKSLEEKVNTTIARYRRGRRAHLQLILT
GKMAHLRKVILSEMSAALKNLCFYSEESPTSYTSVGPDSGRLKFALSYKE
QVGGNRELYIGDLRTKMFTRLIEDYFESFSSFFSGSCLNNDKEFENAILS
MTINVREGFLNYSMDHSKWGPMMCPFLFLMFLQNLKLGDDQYVRSGKDHV
STLLTWHMHKLVEVPFPVVNAMMKSYVKSKLKETTVTERIFRQYFEMGIV
PSHISSLIDMGQGILHNASDFYGLLSERFINYCIGVIFGERPEAYTSSDD
QITLFDRRLSDLVVSDPEEVLVLLEFQSHLSGLLNKFISPKSVAGRFAAE
FKSRFYVWGEEVPLLTKFVSAALHNVKCKEPHQLCETIDTIADQAIANGV
PVSLVNSIQRRTLDLLKYANFPLDPFLLNTNTDVKDWLDGSRGYRIQRLI
EELCPNETKVVRKLVRKLHHKLKNGEFNEEFFLDLFNRDKKEAILQLGDL
LGLEEDLNQLADVNWLNLNEMFPLRMIPSLIKTLQNKLCISSGFIGLCKT
LGSRCVRNKNRENLYIKKLLEDLTTDDHVTRVCNRDGITLYICDKQSHPE
AHRDHICLLRPLLWDYICISLSNSFELGVWVLAEPKVNLNQVIQSVRRLY
PKIFEDQLLPIKFLDLCVLIDINSESLSLISHVVKWKRDEHYTVLFSDLA
NSH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7x6s Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x6s Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D1182 D1322 E1372
Binding residue
(residue number reindexed from 1)		D915 D1050 E1100
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x6s, PDBe:7x6s, PDBj:7x6s
PDBsum7x6s
PubMed37038286
UniProtP14240|L_LYCVA RNA-directed RNA polymerase L (Gene Name=L)

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