Structure of PDB 7x5b Chain A Binding Site BS01

Receptor Information
>7x5b Chain A (length=312) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RAIRPLKLADYIGQPSVREQMELFIHAARGRQEALDHTLIFGPPGLGKTT
LANIIAQEMGVSIKSTSGPVLERPGDLAALLTNLEAGDVLFVDEIHRLSP
IVEEVLYPAMEDFQLDIMIGRSIKLDLPPFTLVGATTRAGMLTNPLRDRF
GIVQRLEFYNVEDLATIVSRSAGILGLEIEPQGAAEIAKRARGTPRIANR
LLRRVRDFAEVRGQGDITRVIADKALNLLDVDERGFDHLDRRLLLTMIDK
FDGGPVGIDNLAAALSEERHTIEDVLEPYLIQQGYIMRTPRGRVVTRHAY
LHFGLNIPKRLG
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7x5b Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x5b Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa.
Resolution2.16 Å
Binding residue
(original residue number in PDB)		R25 P26 Y32 I33 G66 G68 K69 T70 T71 Y185 I193 P221 R222
Binding residue
(residue number reindexed from 1)		R4 P5 Y11 I12 G45 G47 K48 T49 T50 Y159 I167 P195 R196
Annotation score5
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0032508 DNA duplex unwinding
GO:0071247 cellular response to chromate
GO:0072715 cellular response to selenite ion
Cellular Component
GO:0005737 cytoplasm
GO:0048476 Holliday junction resolvase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x5b, PDBe:7x5b, PDBj:7x5b
PDBsum7x5b
PubMed37025142
UniProtQ51426|RUVB_PSEAE Holliday junction branch migration complex subunit RuvB (Gene Name=ruvB)

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