Structure of PDB 7x06 Chain A Binding Site BS01

Receptor Information
>7x06 Chain A (length=804) Species: 1094619 (Phytophthora sojae strain P6497) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPSIRSCGSQQYVTSYIPTGAAFPPSSVQDMISSMKSYASATDLVRTYS
EIPSVEEALSTLDRAAAALNARRYRDALKLYLEGGYAMANVAERQANPKI
CNLLTSKGFETLNWCARLCDWIEGRIKEKHPRPGVHKVGIPVSNWDEDWV
GPFMDEEEARRMWYTPVYCPHPIDFSNLGYRLRCVETGRRPRLMICITMY
NEGPQQLKATLKKLANNLAYLKEQMPGDEKSLTGAFAGDDVWQNVLVCIV
ADGREQVHPKTLDYLEAIGLYDEDLLTINSAGIGAQCHLFEHTLQLSVNG
KCLLPIQTVFALKENKASKLDSHHWYFNAFAEQIQPEYTAVMDVGTMLTK
SALYHLLFAFERNHQIGGACGQLTVDNPFENLSNWVISAQHFEYKISNIL
DKSLESCFGFISVLPGAFSAYRYEAIRGAPLDAYFQTLNIELDVLGPFIG
NMYLAEDRILSFEVVARKNCNWTMHYVKDAVARTDVPHDLVGLISQRKRW
LNGAFFATLFSIWNWGRIYSESKHTFVRKMAFLVFYVYHLLYTAFGFFLP
ANLYLALFFIVFQGFQQNRLEFIDTSEYSQTVLDCAVYIYNFSYLFGLLM
LIIIGLGNNPKHMKLTYYFVGAVFGLMMMLSSLVGAGIFFSTPATVHSIV
VSILTVGVYFIASALHGEVHHIFMTFTHYTALIPSFVNIFTIYSFCNLQD
LSETEKGDFKDVIAKRRALEELRREEKERVENRKKNFEAFRTNVLLTWAF
SNLIFALFVVYFASSSTYMPVLYIFVASLNTCRLLGSIGHWVYIHTEGLR
GRVI
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain7x06 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7x06 Structural basis for directional chitin biosynthesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T237 Y239 E241 D291 K358 D382 R538
Binding residue
(residue number reindexed from 1)		T198 Y200 E202 D252 K319 D343 R499
Annotation score3
Enzymatic activity
Enzyme Commision number 2.4.1.16: chitin synthase.
Gene Ontology
Molecular Function
GO:0004100 chitin synthase activity
GO:0016757 glycosyltransferase activity
GO:0016758 hexosyltransferase activity
Biological Process
GO:0006031 chitin biosynthetic process
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0030428 cell septum
GO:0071944 cell periphery

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7x06, PDBe:7x06, PDBj:7x06
PDBsum7x06
PubMed36131020
UniProtG4Z2L3

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