Structure of PDB 7wxx Chain A Binding Site BS01

Receptor Information

>7wxx Chain A (length=164) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLH
FRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFD
EDERWTDGSSLGINFLYAATHQLGHSLGMGHSSDPNAVMYPTYQNFKLSQ
DDIKGIQKLYGKRS

Ligand information

>7wxx Chain B (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EGLV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wxx Discovery of Highly Potent and Selective Matrix Metalloproteinase-7 Inhibitors by Hybridizing the S1' Subsite Binder with Short Peptides.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	F98 Y167 L176 A177 H178 A179 F180 A211 H214 H218 H224 P234
Binding residue (residue number reindexed from 1)	F5 Y74 L83 A84 H85 A86 F87 A118 H121 H125 H131 P141

Enzymatic activity

Enzyme Commision number

3.4.24.23: matrilysin.

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Cellular Component

External links

PDB	RCSB:7wxx, PDBe:7wxx, PDBj:7wxx
PDBsum	7wxx
PubMed	36137271
UniProt	P09237\|MMP7_HUMAN Matrilysin (Gene Name=MMP7)

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