Structure of PDB 7wwq Chain A Binding Site BS01

Receptor Information
>7wwq Chain A (length=386) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDEIDQYLSKQDGKIDEDYLNHLEPPVKHMSFHAYIRKLTGISCITLNRQ
KYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRA
EVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSE
DTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFV
TAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKEVPDV
FYKDVDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIE
NRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDS
ISLLLEAVRTRNEELAQTWKRSEQWATIEQLCSTVG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wwq Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		Q247 N283 S284 L285 E286 L287 D314 V316 R329 E339 E340 T343 D346 P402 C403 K404 D405 Y411
Binding residue
(residue number reindexed from 1)		Q79 N115 S116 L117 E118 L119 D146 V148 R161 E171 E172 T175 D178 P234 C235 K236 D237 Y243
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process

View graph for
Biological Process
External links
PDB RCSB:7wwq, PDBe:7wwq, PDBj:7wwq
PDBsum7wwq
PubMed36087575
UniProtQ8TAT6|NPL4_HUMAN Nuclear protein localization protein 4 homolog (Gene Name=NPLOC4)

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