Structure of PDB 7wv5 Chain A Binding Site BS01

Receptor Information
>7wv5 Chain A (length=659) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLT
SLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTEL
HLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLL
SNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFL
NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM
LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN
LKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL
INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFS
WLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFAL
VPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEG
LEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP
VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKK
VFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCN
TPPHYHGFP
Ligand information
>7wv5 Chain E (length=46) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccccccccccccccccccccccccccccccccccccccccccccc
..............................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wv5 TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H39 K41 H60 Q62 F84 H108 E110 A519 K619
Binding residue
(residue number reindexed from 1)		H11 K13 H32 Q34 F56 H80 E82 A491 K591
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7wv5, PDBe:7wv5, PDBj:7wv5
PDBsum7wv5
PubMed36371424
UniProtO15455|TLR3_HUMAN Toll-like receptor 3 (Gene Name=TLR3)

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