Structure of PDB 7wnt Chain A Binding Site BS01

Receptor Information
>7wnt Chain A (length=529) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPPPGPLTSGGLRVTALGGINEIGRNMTVFEHLGRLLIIDCGVLFPGHDE
PGVDLILPDMRHVEDRLDDIEALVLTHGHEDHIGAIPFLLKLRPDIPVVG
SKFTLALVAEKCREYRITPVFVEVREGQSTRHGVFECEYFAVNHSTPDAL
AIAVYTGAGTILHTGDIKFDQLPPDGRPTDLPGMSRLGDTGVDLLLCDST
NAEIPGVGPSESEVGPTLHRLIRGADGRVIVACFASNVDRVQQIIDAAVA
LGRRVSFVGRSMVRNMRVARQLGFLRVADSDLIDIAAAETMAPDQVVLIT
TGTQGEPMSALSRMSRGEHRSITLTAGDLIVLSSSLIPGNEEAVFGVIDA
LSKIGARVVTNAQARVHVSGHAYAGELLFLYNGVRPRNVMPVHGTWRMLR
ANAKLAASTGVPQESILLAENGVSVDLVAGKASISGAVPVGKMFVDGLIA
GDVGDITLGERLILSSGFVAVTPHLHSRGFSEDPKALEPAVRKVEAELES
LVIRIAQGVRRTVGKWVGETYRRQPMIVP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7wnt Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7wnt Structural ans functional study of RNase J from Mycobacterium tuberculosis
Resolution2.44 Å
Binding residue
(original residue number in PDB)		H81 H83 H148 D170
Binding residue
(residue number reindexed from 1)		H77 H79 H144 D166
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.5.2.6: beta-lactamase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004527 exonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wnt, PDBe:7wnt, PDBj:7wnt
PDBsum7wnt
PubMed
UniProtP9WGZ9|RNJ_MYCTU Ribonuclease J (Gene Name=rnj)

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