Structure of PDB 7wmh Chain A Binding Site BS01

Receptor Information
>7wmh Chain A (length=231) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPKVDLEAFSHFTKI
ITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPES
ETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQA
VLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKV
TDLRMIGACHASRFLHMKPTELFPPLFLEVF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wmh Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		K288 I302 L454 E457
Binding residue
(residue number reindexed from 1)		K63 I77 L226 E229
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wmh, PDBe:7wmh, PDBj:7wmh
PDBsum7wmh
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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