Structure of PDB 7wlx Chain A Binding Site BS01

Receptor Information
>7wlx Chain A (length=230) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPDLEAFSHFTKIIT
PAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESET
LTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVL
LMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTD
LRMIGACHASRFLHMKCPTELFPPLFLEVF
Ligand information
Receptor-Ligand Complex Structure
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PDB7wlx Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		K288 K306 L454 E457
Binding residue
(residue number reindexed from 1)		K61 K79 L225 E228
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wlx, PDBe:7wlx, PDBj:7wlx
PDBsum7wlx
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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