Structure of PDB 7wiz Chain A Binding Site BS01

Receptor Information
>7wiz Chain A (length=556) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTF
SPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEK
ERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTI
GDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSV
RELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIY
HVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVC
IAVVGKYTKFTDSYASVVKALQHAALAVNRKLELVFIESCLLEEETLHSE
PSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWARENQKPLLGICL
GLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRL
GKRITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFV
GTDVDKTRMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDR
LNQYIQ
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain7wiz Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wiz Structural basis for ligand binding modes of CTP synthase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		G371 G372 F373 C399 L400 Q403 H480 Y482
Binding residue
(residue number reindexed from 1)		G371 G372 F373 C399 L400 Q403 H480 Y482
Annotation score5
Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7wiz, PDBe:7wiz, PDBj:7wiz
PDBsum7wiz
PubMed34301892
UniProtQ9VUL1|PYRG_DROME CTP synthase (Gene Name=Ctps)

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