Structure of PDB 7wfc Chain A Binding Site BS01

Receptor Information

>7wfc Chain A (length=309) Species: 290028 (Human coronavirus HKU1)

KIDVLLTVDGVNFKSISLTVGEVFGKILGNVFCDGIDVTKLKCSDFYADK
ILYQYENLSLADISAVQSSFGFDQQQLLAYYNFLTVCKWSVVVNGPFFSF
EQSHNNSYVNVACLMLQHINLKFNKWQWQEAWYEFRAGRPHRLVALVLAK
GHFKFDEPSDATDFIRVVLKQADLSGAICELELICDCGIKQESRVGVDAV
MHFGTLAKTDLFNGYKIGCNCAGRIVHCTKLNVPFLICSNTPLSKDLPDD
VVAANMFMGVGVGHYTHLKCGSPYQHYDACSVKKYTGVSGCLTDCLYLKN
LTQTFTSML

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7wfc Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wfc The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): C187 C221 C223
• Binding residue (residue number reindexed from 1): C185 C219 C221
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.50: mRNA guanylyltransferase.
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0008234 cysteine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:7wfc, PDBe:7wfc, PDBj:7wfc
• PDBsum: 7wfc
• PubMed: 37130166
• UniProt: U3N841