Structure of PDB 7wah Chain A Binding Site BS01

Receptor Information
>7wah Chain A (length=1473) Species: 45657 (Desulfonema ishimotonii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNT
KGRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQ
LRQRSTLRWTDKNPCPDNAETYCPFCELLGRSFRIHFGNLSLPGKPDFDG
PKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDNKVSAE
ARKLLCDSLKFTDRLCGALCVIRFDNLAEKTAEQIISILDDNKKTEYTRL
LADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGVTIRQILTTSADTKEL
KNAGKWREFCEKLGEALYLKSKSVLKETVVCGELVAKTPFFFGAIDEDAK
QTALQVLLTPDNKYRLPRSAVRGILRRDLQTYFDSPCNAELGGRPCMCKT
CRIMRGITVMDARSEYNAPPEIRHRTRINPFTGTVAEGALFNMEVAPEGI
VFPFQLRYRGSEDGLPDALKTVLKWWAEGQAFMSGAASTGKGRFRMENAK
YETLDLSDENQRNDYLKNWGWRDEKGLEELKKRLNSGLPEPGNYRDPKWH
EINVSIEMASPFINGDPIRAAVDKRGTAVVTFVKYKAEGEEAKPVCAYKA
ESFRGVIRSAVARIHMEDGVPLTELTHSDCECLLCQIFGSEYEAGKIRFE
DLVFESDPEPVTFDHVAIDRFTGGAAAKKKFDDSPLPGSPARPLMLKGSF
WIRRDVLEDEEYCKALGKALADVNNGLYPLGGKSAIGYGQVKSLGIKGDD
KRISRLMNAVPEKPKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQ
KFHEGRLTGKIRCKLITKTPLIVPDTSNDDFFRPYHKSYAFFRLHKQIMI
PGSELRGMVSSVYETVTNSCFRIFDETKRLSWRMDADQDFLPGRVTADGK
HIQKFSETARVPFYDKTQKHFDILDEQEIAGEKPVRMWVKRFIKRLSLVD
PAKHWKRRKEGIATFIEQKNGSYYFNVVTNNGCTSFHLWHKPDNFDQEKL
EGIQNGEKLDCWVRDSRYQKAFQEIPENDPDGWECKEGYLHVVGPSKVEF
SDKKGDVINNFQGTLPSVPNDWKTIRTNDFKNRKRKNEPVFCCEDDKGNY
YTMAKYCETFFFDLKENEEYEIPEKARIKYKELLRVYNNNPQAVPESVFQ
SRVARENVEKLKSGDLVYFKHNEKYVEDIVPVRISRTVDDRMIGKRMSAD
LRPCHGDWKGLCPACRLFGTGSYKGRVRFGFASLENDPEWLIPGKNPGDP
FHGGPVMLSLLERPRPTWSIPGSDNKFKVPGRKFYVHHHAWKTIKDGNHP
TTGKAIEQSPNNRTVEALAGGNSFSFEIAFENLKEWELGLLIHSLQLEKG
LAHKLGMAKSMGFGSVEIDVESVRLRKDWKQWRNGNSEIPNWLGKGFAKL
KEWFRDELDFIENLKKLLWFPEGDQAPRVCYPMLRKKDDPNGNSGYEELK
DGEFKKEDRQKKLTTPWTPWASS
Ligand information
>7wah Chain R (length=39) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gugaugucacggaaccuuuguugucuucgacauggguaa
.......................................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wah Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex.
Resolution2.45 Å
Binding residue
(original residue number in PDB)
E13 R35 Q37 F39 H43 R53 Y55 G58 T59 L60 R62 R67 K89 F90 D91 T92 K95 R97 Q100 L101 R102 Q103 R104 L129 H149 F150 N152 K158 V172 L173 N174 R175 V176 G181 D185 F186 F187 R227 G419 R444 S445 A446 R448 G449 I450 R453 L467 G468 G469 P471 R481 T484 V485 H500 R501 T502 R503 I504 T510 L516 F517 G561 A562 A563 S564 N640 G641 P643 K675 E677 S678 R680 G681 V682 R684 S716 E719 A720 D740 H741 V742 A743 I744 R746 G749 K756 F757 G808 K809 A811 P908 T910 S948 E949 R951 R967 R978 R1010 R1045 H1098 K1099 S1124 R1125 S1154 K1155 R1193 N1195 E1196 K1213 Y1214 C1215 Y1245 N1248 Q1250 V1290 R1291 I1292 R1294 G1349 T1350 G1351 Y1353 K1354 L1391 E1392 R1393 P1394 R1395 T1397 W1398 Y1415 R1443 G1486 A1488 K1489 Y1561 L1564 Y1576 E1577
Binding residue
(residue number reindexed from 1)
E13 R35 Q37 F39 H43 R53 Y55 G58 T59 L60 R62 R67 K89 F90 D91 T92 K95 R97 Q100 L101 R102 Q103 R104 L129 H136 F137 N139 K145 V159 L160 N161 R162 V163 G168 D172 F173 F174 R214 G343 R368 S369 A370 R372 G373 I374 R377 L391 G392 G393 P395 R405 T408 V409 H424 R425 T426 R427 I428 T434 L440 F441 G485 A486 A487 S488 N564 G565 P567 K599 E601 S602 R604 G605 V606 R608 S640 E643 A644 D664 H665 V666 A667 I668 R670 G673 K680 F681 G732 K733 A735 P824 T826 S853 E854 R856 R872 R883 R910 R945 H990 K991 S1016 R1017 S1046 K1047 R1085 N1087 E1088 K1105 Y1106 C1107 Y1137 N1140 Q1142 V1182 R1183 I1184 R1186 G1219 T1220 G1221 Y1223 K1224 L1261 E1262 R1263 P1264 R1265 T1267 W1268 Y1285 R1313 G1356 A1358 K1359 Y1431 L1434 Y1446 E1447
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:7wah, PDBe:7wah, PDBj:7wah
PDBsum7wah
PubMed35643083
UniProtA0A401FT36

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