Structure of PDB 7w73 Chain A Binding Site BS01

Receptor Information
>7w73 Chain A (length=1224) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFRRFFSKFNVQAPAVVVLGGYLPIGENQGVNSTWYCAGQHPTASGVHGI
FVSHIRGGHGFEIGISQEPFDPSGYQLYLHKATNGNTNATARLRICQFPS
IKTLGPTANNDVTIGRNCLFNKAIPAHMSEHSVVGITWDNDRVTVFSDKI
YYFYFKNDWSRVATKCYNSGGCAMQYVYEPTYYMLNVTSAGEDGISYQPC
TANCIGYAANVFATEPNGHIPEGFSFNNWFLLSNDSTLVHGKVVSNQPLL
VNCLLAIPKIYGLGQFFSFNQTIDGVCNGAAVQRAPEALRFNINDTSVIL
AEGSIVLHTALGTNFSFVCSNSSNPHLATFAIPLGATQVPYYCFFKVDTY
NSTVYKFLAVLPPTVREIVITKYGDVYVNGFGYLHLGLLDAVTINFTGHG
TDDDVSGFWTIASTNFVDALIEVQGTAIQRILYCDDPVSQLKCSQVAFDL
DDGFYPFSSRNLLSHEQPISFVTLPSFNAHSFVNITVSASFGGHSGANLI
ASDTTINGFSSFCVDTRQFTISLSYNVTNSYGYVSNSQDSNCPFTLQSVN
DYLSFSKFCVSTSLLASACTIDLFGYPEFGSGVKFTSLYFQFTKGELITG
TPKPLEGVTDVSFMTLDVCTKYTIYGFKGEGIITLTNSSFLAGVYYTSDS
GQLLAFKNVTSGAVYSVTPCSFSEQAAYVDDDIVGVISSLSSSTFNSTRE
LPGFFYHSNDGSNCTEPVLVYSNIGVCKSGSIGYVPSQSGQVKIAPTVTG
NISIPTNFSMSIRTEYLQLYNTPVSVDCATYVCNGNSRCKQLLTQYTAAC
KTIESALQLSARLESVEVNSMLTISEEALQLATISSFNGDGYNFTNVLGV
SVYDPARGRVVQKRSFIEDLLFNKVVTNGLGTVDEDYKRCSNGRSVADLV
CAQYYSGVMVLPGVVDAEKLHMYSASLIGGMVLGGFTAAAALPFSYAVQA
RLNYLALQTDVLQRNQQLLAESFNSAIGNITSAFESVKEASSQTSRGLNT
VAHALTKVQEVVNSQGAALTQLTVQLQHNFQAISSSIDDIYSRLDILSAD
VQVDRLITGRLSALNAFVAQTLTKYTEVQASRKLAQQKVNECVKSQSQRY
GFCGGDGEHIFSLVQAAPQGLLFLHTVLVPSDFVDVIAIAGLCVNDEIAL
TLREPGLVLFTHELQNHTATEYFVSSRRMFEPRKPTVSDFVQIESCVVTY
VNLTRDQLPDVIPDYIDVNKTRDE
Ligand information
Ligand IDBMA
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-RWOPYEJCSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-mannopyranose;
beta-D-mannose;
D-mannose;
mannose
ChEMBL
DrugBank
ZINCZINC000003830679
PDB chain7w73 Chain t Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w73 In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.
Resolution6.4 Å
Binding residue
(original residue number in PDB)		A886 R887
Binding residue
(residue number reindexed from 1)		A856 R857
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0033644 host cell membrane
GO:0044173 host cell endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w73, PDBe:7w73, PDBj:7w73
PDBsum7w73
PubMed35986008
UniProtA0A1Y0DD46

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