Structure of PDB 7w6z Chain A Binding Site BS01

Receptor Information

>7w6z Chain A (length=414) Species: 523791 (Kangiella koreensis DSM 16069) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MTDFLYSIFGLLILLGVLVTFHEWGHYWVAKKLGVKALRFSVGFGKPIWG
RTNKHGTEFVIAPIPLGGYVRFVDEREGEVAEADLPFAFNRQQVWKRILI
VLAGPMANFLLAIVVYAAVYMMGIAVGKPFVTNVLPNTVAAQANFPENSE
ILSVDGVQVKSLEDAIFAFVDHIDDDKTIKVVVKPLNQEPTTVVLDVSQW
QEPDEGTIFDSLGLGFGRVNGEPSLGLVAKDSPAEKGGLKVGDTVVSVNG
ESISLWSEFVSFIENNPGKPLELIVARDGYQQPLVVTPEANERDRTIGYL
GISPAFQGYNVINYGFFESFGKGAEQTWVMVERIGSFLGKLITAQAGMVA
FLLYLAMISVNLGFVNLLPIPMLDGGHLMYYLVELVGIILVLTIMAIALF
FDINRINQLESSFQ

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7w6z Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7w6z Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
Resolution	3.15 Å
Binding residue (original residue number in PDB)	H22 H26 D395
Binding residue (residue number reindexed from 1)	H22 H26 D374
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.4.24.-

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7w6z, PDBe:7w6z, PDBj:7w6z
PDBsum	7w6z
PubMed	36001659
UniProt	C7R5Z1

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