Structure of PDB 7w6x Chain A Binding Site BS01

Receptor Information

>7w6x Chain A (length=447) Species: 83333 (Escherichia coli K-12)

MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWR
RTDKLGTEYVIALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAI
IAAGPVANFIFAIFAYWLVFIIGVPGVRPVVGEIAANSIAAEAQIAPGTE
LKAVDGIETPDWDAVRLQLVDKIGDESTTITVAPFGSDQRRDVKLDLRHW
AFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGLQAGDRIVKVD
GQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIG
FVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLIT
GDVKLNNLSGPISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPV
LDGGHLLFLAIEKIKGGPVSERVQDFCYRIGSILLVLLMGLALFNDF

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 7w6x Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7w6x Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): H22 H26 D402
• Binding residue (residue number reindexed from 1): H22 H26 D402
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.-

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0043856 anti-sigma factor antagonist activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0036460 cellular response to cell envelope stress
• GO:0045893 positive regulation of DNA-templated transcription

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:7w6x, PDBe:7w6x, PDBj:7w6x
• PDBsum: 7w6x
• PubMed: 36001659
• UniProt: P0AEH1|RSEP_ECOLI Regulator of sigma-E protease RseP (Gene Name=rseP)