Structure of PDB 7w6u Chain A Binding Site BS01

Receptor Information
>7w6u Chain A (length=597) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STTEDLAKTFLEKFNSEAEELSHQSSLASWSYNTNITDENVQKMNEAGAR
WSAFYEEQCKLAKTYPLEEIQNLTVKRQLQALQQSGSSVLSADKSKRLNE
ILNTMSTIYSTGKVCNPSNPQECLLLEPGLDAIMENSKDYNQRLWAWEGW
RSEVGKQLRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGPSGYDYS
RDQLIEDVERTFAEIKPLYEHLHAYVRAKLMDTYPSHINPTGCLPAHLLG
DMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQSWDAKRIFEEAEKFFVSV
GLPNMTQGFWENSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMDD
FLTAHHEMGHIQYDMAYAVQPYLLRNGANEGFHEAVGEIMSLSAATPNHL
KAIGLLPPDFYEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEI
PKEEWMKKWWEMKREIVGVVEPVPHDETYCDPAALFHVANDYSFIRYYTR
TIYQFQFQEALCQTAKHEGPLHKCDISNSTEAGQKLLQMLSLGKSEPWTL
ALERIVGVKNMDVRPLLNYFEPLFTWLKDQNKNSFVGWSTNWSPYAH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7w6u Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7w6u Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses
Resolution2.56 Å
Binding residue
(original residue number in PDB)		H374 H378 E402
Binding residue
(residue number reindexed from 1)		H356 H360 E384
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w6u, PDBe:7w6u, PDBj:7w6u
PDBsum7w6u
PubMed
UniProtF6V9L3

[Back to BioLiP]