Structure of PDB 7w3r Chain A Binding Site BS01

Receptor Information
>7w3r Chain A (length=340) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RFVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDMKHKTTLLELQ
KMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIE
EMSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKNI
YESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRY
TFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMESYEYDLIGVTVHTGTA
DGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTT
KTFMDFSFEKTHSAYMLFYKRMEPEREYKFDVSSELLEWI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7w3r Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7w3r Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		C2018 H2020 C2062
Binding residue
(residue number reindexed from 1)		C127 H129 C171
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:7w3r, PDBe:7w3r, PDBj:7w3r
PDBsum7w3r
PubMed35588869
UniProtQ70CQ2|UBP34_HUMAN Ubiquitin carboxyl-terminal hydrolase 34 (Gene Name=USP34)

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