Structure of PDB 7w3q Chain A Binding Site BS01

Receptor Information

>7w3q Chain A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS

Ligand information

>7w3q Chain C (length=9) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KILHRLLQD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7w3q Crystal structure of RORgamma in complex with natural inverse agonist
Resolution	2.0 Å
Binding residue (original residue number in PDB)	K336 Q346 E504
Binding residue (residue number reindexed from 1)	K72 Q82 E239

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7w3q, PDBe:7w3q, PDBj:7w3q
PDBsum	7w3q
PubMed
UniProt	P51449\|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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