Structure of PDB 7w29 Chain A Binding Site BS01

Receptor Information
>7w29 Chain A (length=475) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVT
FDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNS
FWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYF
YKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLAL
IPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAE
FVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFAL
HFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSW
DNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLG
EKEILEKAVKSAAVNREYYRQQMEE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w29 Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		M151 N153 I154 R214 Q215 M251 Q254 N255 P258 W273 T285 G286 L289 Y312 R315 H323
Binding residue
(residue number reindexed from 1)		M132 N134 I135 R195 Q196 M232 Q235 N236 P239 W254 T266 G267 L270 Y293 R296 H304
Enzymatic activity
Enzyme Commision number 2.1.1.85: protein-histidine N-methyltransferase.
Gene Ontology
Molecular Function
GO:0018064 protein-L-histidine N-tele-methyltransferase activity
Biological Process
GO:0030047 actin modification

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Molecular Function
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Biological Process
External links
PDB RCSB:7w29, PDBe:7w29, PDBj:7w29
PDBsum7w29
PubMed35481649
UniProtQ86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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