Structure of PDB 7w28 Chain A Binding Site BS01

Receptor Information
>7w28 Chain A (length=478) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVT
FDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNS
FWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYF
YKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLAL
IPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAE
FVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFAL
HFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSW
DNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLG
EKEILEKAVKSAAVNREYYRQQMEEKAP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7w28 Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		M151 N153 N211 R214 Q215 Q254 N255 P258 W273 D274 I283 T285 G286 Y287 Y312 R315
Binding residue
(residue number reindexed from 1)		M132 N134 N192 R195 Q196 Q235 N236 P239 W254 D255 I264 T266 G267 Y268 Y293 R296
Enzymatic activity
Enzyme Commision number 2.1.1.85: protein-histidine N-methyltransferase.
Gene Ontology
Molecular Function
GO:0018064 protein-L-histidine N-tele-methyltransferase activity
Biological Process
GO:0030047 actin modification

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Molecular Function
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Biological Process
External links
PDB RCSB:7w28, PDBe:7w28, PDBj:7w28
PDBsum7w28
PubMed35481649
UniProtQ86TU7|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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