Structure of PDB 7vza Chain A Binding Site BS01

Receptor Information
>7vza Chain A (length=368) Species: 1946 (Streptomyces kasugaensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMALRVGIVYGTRPEAIKLAPLVLALDADPGFEPVIITTGMLDEINELFG
LRPRHNLDIMRPGQRLSAMASRIVGELGDPLLDELVDVAVVQGDTSTAFA
AAYAAACERIPVAHLEAGLRTGDRFEPFPEEINRRLITQLADLHFAPTAD
AAGNLLAEGVRSDDVYVTGNTVIDAMHLVLDRPGDSANRELDAFTEGRQT
VLLTMHRRESWGIPMGRVAAAVAELCRSRPTLRFVIPLHPNPEVRRVFRS
HLSSLTQVLLCEPLRYSEFIRLMHRAVLVLTDSGGVQEEAPTLGKPVLVL
RDRTERPEGIAAGCARLVGTDPALIVKEVGRLLDDPEAYEAMRRVCYGEG
DAAARCLEALRERWLSSP
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain7vza Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vza KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity.
Resolution2.58 Å
Binding residue
(original residue number in PDB)		R12 P13 H209 L267 Y269 F272 S286 E292
Binding residue
(residue number reindexed from 1)		R13 P14 H206 L264 Y266 F269 S283 E289
Annotation score2
Enzymatic activity
Enzyme Commision number 5.1.3.14: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity
GO:0016853 isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:7vza, PDBe:7vza, PDBj:7vza
PDBsum7vza
PubMed35203422
UniProtA0A0K1H2R6

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