Structure of PDB 7vse Chain A Binding Site BS01

Receptor Information

>7vse Chain A (length=155) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MLKQVEIFTDGSCLGNPGPGGYGAILRYRGREKTFSAGYTRTTNNRMELM
AAIVALEALKEHCEVILSTDSQYVRQGITQWIHNWKKRGWKTADKKPVKN
VDLWQRLDAALGQHQIKWEWVKGHAGHPENERCDELARAAAMNPTLEDTG
YQVEV

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

7vse Chain A Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7vse Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography.
Resolution	2.08 Å
Binding residue (original residue number in PDB)	D10 D70 H124
Binding residue (residue number reindexed from 1)	D10 D70 H124
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.26.4: ribonuclease H.

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003676	nucleic acid binding
GO:0004519	endonuclease activity
GO:0004523	RNA-DNA hybrid ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006401	RNA catabolic process
GO:0043137	DNA replication, removal of RNA primer

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:7vse, PDBe:7vse, PDBj:7vse
PDBsum	7vse
PubMed	35234152
UniProt	P0A7Y4\|RNH_ECOLI Ribonuclease HI (Gene Name=rnhA)

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