Structure of PDB 7vpg Chain A Binding Site BS01

Receptor Information
>7vpg Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDS
GQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIA
QHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCY
CADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDK
QNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNTNTSAPQDIYA
VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNH
NGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRN
Ligand information
>7vpg Chain X (length=13) Species: 694009 (Severe acute respiratory syndrome-related coronavirus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SELDDEEPMELDY
Receptor-Ligand Complex Structure
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PDB7vpg Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
Resolution2.49 Å
Binding residue
(original residue number in PDB)		R239 T256 F257 K258 W300 D301 R305 T306 K307 K309 R365
Binding residue
(residue number reindexed from 1)		R215 T232 F233 K234 W275 D276 R280 T281 K282 K284 R340
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0043130 ubiquitin binding
Biological Process
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006913 nucleocytoplasmic transport
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0071407 cellular response to organic cyclic compound
Cellular Component
GO:0000922 spindle pole
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0097431 mitotic spindle pole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vpg, PDBe:7vpg, PDBj:7vpg
PDBsum7vpg
PubMed35096974
UniProtP78406|RAE1L_HUMAN mRNA export factor RAE1 (Gene Name=RAE1)

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