Structure of PDB 7vhf Chain A Binding Site BS01

Receptor Information
>7vhf Chain A (length=283) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
REFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSVSVINHTPPGSYF
AVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHISV
PGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTM
TRDASRAVLRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTL
NWGRISNVLPEYRGEDGVRVGRISFNNISAILGTVAVILNCHQPECQITG
DRPVIKINNTLWESNTAAAFLNRKSQFLYTTGK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7vhf A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		Y77 V78 D94 F95 S112 S113 Y114 E167 R170 T199
Binding residue
(residue number reindexed from 1)		Y77 V78 D94 F95 S112 S113 Y114 E167 R170 T199
Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030598 rRNA N-glycosylase activity
GO:0090729 toxin activity
Biological Process
GO:0017148 negative regulation of translation
GO:0035821 modulation of process of another organism

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7vhf, PDBe:7vhf, PDBj:7vhf
PDBsum7vhf
PubMed35794188
UniProtQ7DI68

[Back to BioLiP]