Structure of PDB 7vgn Chain A Binding Site BS01

Receptor Information
>7vgn Chain A (length=338) Species: 66854 (Saccharothrix mutabilis subsp. capreolus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTAIREIRLSEPESAQAALLALECAQRYAEPDSADFLADAAVLAHDLPRA
VRREVERARLDDRLHALVVRGNDVDQDALGPTPPHWRQARTAASRRYGFL
LVLYASLLGDVVGWATQQDGRVVTDVLPIEGQEDSLVSSSSSVELGWHTE
DAFSPYRADYVGLFSLRNPDSVATTVAGLDPDLVGPAVVDVLFGERFHIR
PDNSHLPTHNSGGRLSDYFAGIVEAVENPRAVSILRGHRDAPQLCVDSDF
TTAVDGDAEAAGALDTLIKHLGGALYEVVLGPGDVAFLDNRNVVHGRRPF
RARFDGTDRWLKRINVTADLRKSRAARRDAQARVLGEA
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain7vgn Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7vgn Crystal structure of the alpha-ketoglutarate-dependent non-heme iron oxygenase CmnC in capreomycin biosynthesis and its engineering to catalyze hydroxylation of the substrate enantiomer.
Resolution1.83 Å
Binding residue
(original residue number in PDB)		V126 L145 E150 T174 H295 R297 R309 R313
Binding residue
(residue number reindexed from 1)		V126 L145 E150 T174 H295 R297 R309 R313
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7vgn, PDBe:7vgn, PDBj:7vgn
PDBsum7vgn
PubMed36176888
UniProtA6YEH4

[Back to BioLiP]