Structure of PDB 7vgm Chain A Binding Site BS01

Receptor Information
>7vgm Chain A (length=571) Species: 226900 (Bacillus cereus ATCC 14579) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKTEIPSHLKPFVSTQHYDQYTPVNHAVWRYIMRQNHSFLKDVAHPAYVN
GLQSSGINIDAIPKVEEMNECLAPSGWGAVTIDGLIPGVAFFDFQGHGLL
PIATDIRKVENIEYTPAPDIVHEAAGHAPILLDPTYAKYVKRFGQIGAKA
FSTKEEHDAFEAVRTLTIVKESPTSTPDEVKAAENAVIEKQNLVSGLSEA
EQISRLFWWTVEYGLIGNIDDPKIYGAGLLSSVGESKHCLTDAVEKVPFS
IEACIGTTYDVTKMQPQLFVCESFEELTDALETFSKTMAFKTGGKEGLEK
AIRSENYATAELNSGLQITGTFSETIENDAGELIYMRTNSPTALALHNKQ
LANHSTSVHSDGFGTPIGLLTENIALENCTDEQLQSLGITIGTIAEFTFA
SGIHVKGTVTDIVKNDKKIALISFIDCTVTYNARVLFDASWGAFDMAVGS
QITSVFPGAADAAAFFPMDEEVHEIPAPLVLNELERMYQTVRDIRSEGIL
HDAHIDQLIAIQEVLNKFYAKEWLLRLEVLELLLEHNKGHETSAALLHQL
STFTTDEAVTRLINNGLALLP
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain7vgm Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vgm Structural studies of a novel auxiliary-domain-containing phenylalanine hydroxylase from Bacillus cereus ATCC 14579.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		H124 H129 E214
Binding residue
(residue number reindexed from 1)		H122 H127 E212
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.16.1: phenylalanine 4-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0046872 metal ion binding
Biological Process
GO:0009072 aromatic amino acid metabolic process
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine

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Molecular Function
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Biological Process
External links
PDB RCSB:7vgm, PDBe:7vgm, PDBj:7vgm
PDBsum7vgm
PubMed35503207
UniProtQ818B4

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