Structure of PDB 7vg3 Chain A Binding Site BS01

Receptor Information
>7vg3 Chain A (length=860) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAGSKKRKELHGTTCANALSGTWGENIDGATFQAYKFDFCCNISGEVYSS
FSLLLESTLAEDVGKVEMDLYLVRKLVKASVSPCGQIRLSQEELVKAKYF
QQFFFNGMFGKLFVGSKSQGTKREFLLQTDTSSLWHPAFMFLLLPVETND
LASSATIDWSAINSCASIVEFLKKNNLIHFANASSDKNSLEELVVIAIHT
GRIYSIVEAVSDSSAMSPFEGYATYAEYFNKKYGIVLAHPNQPLMKLKQS
HHAHNLLVDFNEEMVRKRKPNIHAHLPPELLARIDVPRAVLKSIYLLPSV
MHRLESLMLASQLREEIDCSIDNFSISSTSILEAVTTLTCPESFSMERLE
LLGDSVLKYVASCHLFLKYPDKDEGQLSRQRQSIISNSNLHRLTTSRKLQ
GYIRNGAFEPRRWTAPGQFSLFPVPCKCGIDTREVPLDPKFFTENMTIKI
GKSCDMGHRWVVSKSVSDCAEALIGAYYVSGGLSASLHMMKWLGIDVDFD
PNLVVEAINRVSLRCYDELIELERKIQHEFSAKFLLKEAITHSSLRESYS
YERLEFLGDSVLDFLITRHLFNTYEQTGPGEMTDLRSACVNNENFAQVAV
KNNLHTHLQRCATVLETQINDYLMSFQKPGRSIPSIQGPKALGDVVESIA
GALLIDTRLDLDQVWRVFEPLLSPLVTPDKLQLPPYRELNELCDSLGYFF
RVKCSNDGVKAQATIQLQLDDVLLTGDGSEQTNKLALGKAASHLLTQLEK
RNISEIQSIVIPFIGPINMKKGGPRGTLHEFCKKHLWPMPTFDTSEEKSR
TPFEFIDGGEKRTSFSSFTSTITLRIPNREAVMYAGEARPDKKSSFDSAV
VELLYELERR
Ligand information
>7vg3 Chain C (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uacaagcgaaugagucauucauccuaaguc
..............................
Receptor-Ligand Complex Structure
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PDB7vg3 Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.
Resolution3.73 Å
Binding residue
(original residue number in PDB)		K625 Q904 H906 R931 L1003 E1039 R1044 F1087 E1224 D1228 S1256 N1261 R1359 K1406 D1544 K1545
Binding residue
(residue number reindexed from 1)		K5 Q249 H251 R266 L338 E374 R379 F422 E555 D559 S587 N592 R687 K734 D841 K842
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006952 defense response
GO:0010267 ta-siRNA processing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0051214 RNAi-mediated antiviral immunity against RNA virus
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vg3, PDBe:7vg3, PDBj:7vg3
PDBsum7vg3
PubMed34648373
UniProtQ9LXW7|DCL3_ARATH Endoribonuclease Dicer homolog 3 (Gene Name=DCL3)

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