Structure of PDB 7vg2 Chain A Binding Site BS01

Receptor Information
>7vg2 Chain A (length=845) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAAGSKKRKELHGTTCANALSGTWGENIDGATFQAYKFDFCCNISGEVYS
SFSLLLESTLAEDVGKVEMDLYLVRKLVKASVSPCGQIRLSQEELVKAKY
FQQFFFNGMFGKLFVGEFLLQTDTSSLWHPAFMFLLLPVETATIDWSAIN
SCASIVEFLKKNNLIHFANASSDKNSLEELVVIAIHTGRIYSIVEAVSDS
SAMSPFGYATYAEYFNKKYGIVLAHPNQPLMKLKQSHHAHNLLVDFNEEV
RKRKPNIHAHLPPELLARIDVPRAVLKSIYLLPSVMHRLESLMLASQLRE
EIDCSIDNFSISSTSILEAVTTLTCPESFSMERLELLGDSVLKYVASCHL
FLKYPDKDEGQLSRQRQSIISNSNLHRLTTSRKLQGYIRNGAFEPRRWTA
PGQFSLFPVPCKCGIDTREVPLDPKFFTENMTIKIGKSCDMGHRWVVSKS
VSDCAEALIGAYYVSGGLSASLHMMKWLGIDVDFDPNLVVEAINRVSLRC
YIPKEDELIELERKIQHEFSAKFLLKEAITHSSLRESYSYERLEFLGDSV
LDFLITRHLFNTYEQTGPGEMTDLRSACVNNENFAQVAVKNNLHTHLQRC
ATVLETQINDYLMSFQKPDETGRSIPSIQGPKALGDVVESIAGALLIDTR
LDLDQVWRVFEPLLSPLVTPDKLQLPPYRELNELCDSLGYFFRVKCSNDG
VKAQATIQLQLDDVLLTGDGSEQTNKLALGKAASHLLTQLEKRNVIPFIG
PINMKKGGPRGTLHEFCKKHLWPMPTFDTSEEKSRTPFEKRTSFSSFTST
ITLRIPNREAVMYAGEARPDKKSSFDSAVVELLYELERRKIVIIQ
Ligand information
>7vg2 Chain C (length=35) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aacaagcgaaugagucauucauccuaagucugcau
...................................
Receptor-Ligand Complex Structure
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PDB7vg2 Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		K625 K626 K628 V693 K903 Q904 H906 H907 H909 N936 I937 L1003 E1039 G1040 S1043 R1044 R1076 F1087 D1228 S1256 V1259 N1260 N1261 E1319 P1356 Y1358 R1359 K1406 S1517 F1521 D1544 K1545
Binding residue
(residue number reindexed from 1)		K6 K7 K9 V74 K234 Q235 H237 H238 H240 N256 I257 L323 E359 G360 S363 R364 R396 F407 D548 S576 V579 N580 N581 E639 P676 Y678 R679 K726 S793 F797 D820 K821
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006952 defense response
GO:0010267 ta-siRNA processing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0051214 RNAi-mediated antiviral immunity against RNA virus
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vg2, PDBe:7vg2, PDBj:7vg2
PDBsum7vg2
PubMed34648373
UniProtQ9LXW7|DCL3_ARATH Endoribonuclease Dicer homolog 3 (Gene Name=DCL3)

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