Structure of PDB 7vfu Chain A Binding Site BS01

Receptor Information
>7vfu Chain A (length=1266) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLD
DTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILAT
AGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLF
FAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDT
ECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTW
NWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI
ERELNGYLEWIFKAEEVMLAEEDRNSYFRRKEKMFRFFIRRMVKAQSFYW
VVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGL
GPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIF
KVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFN
FQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSS
FYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQ
KAKEVAARSVWEQRASQLRLQNLRASRRFCHYIVTMRYFEVVILVVIALS
SIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGA
YFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIK
RLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTD
ESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVST
GEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVA
LIIITFQEQKNERACIDFAISAPQNRQSFQYKTWTFVVSPPFEYFIMAMI
ALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYF
RDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQ
GYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDDTS
INRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATECGS
DFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIR
VWANDMFEMLKHMSVHFTSTLMALIRTALEITKQHQCDAELRKEISVVWA
NLPQKTLDLLVPPHKP
Ligand information
>7vfu Chain E (length=25) Species: 6492 (Conus magus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CKGKGAKCSRLMYDCCTGSCRSGKC
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vfu Closed-state inactivation and pore-blocker modulation mechanisms of human Ca V 2.2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E640 T641 P642 T643 T644 D664 A667 Y1310 D1345 P1368 M1369 K1372 D1628 D1629 T1630 N1633 E1659
Binding residue
(residue number reindexed from 1)		E504 T505 P506 T507 T508 D528 A531 Y797 D832 P855 M856 K859 D1097 D1098 T1099 N1102 E1128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding
GO:0005216 monoatomic ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008331 high voltage-gated calcium channel activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007268 chemical synaptic transmission
GO:0050804 modulation of chemical synaptic transmission
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0098703 calcium ion import across plasma membrane
GO:1904645 response to amyloid-beta
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0043025 neuronal cell body
GO:0045202 synapse

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vfu, PDBe:7vfu, PDBj:7vfu
PDBsum7vfu
PubMed34731621
UniProtQ00975|CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (Gene Name=CACNA1B)

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