Structure of PDB 7vdv Chain A Binding Site BS01

Receptor Information
>7vdv Chain A (length=809) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVDPVEILQEREYR
LQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEVVVC
MRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQ
EYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKKLIDQK
KDKRLAYLLQQTYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSL
YNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNW
AYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKH
ILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPLQNKL
PELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRL
HKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLL
TDGSGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLY
RASGKFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRL
DGTTKAEDRGMLLKTFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDS
DWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQ
KVIQAGMFDQKSSSHERRAFLQAILEHEEQDEEEDEVPDDETVNQMIARH
EEEFDLFMRMDLDRRREEARNPKRKPRLMEEDELPSWIIKEKMFGRGSRH
RKEVDYSDS
Ligand information
>7vdv Chain I (length=135) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggtgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaac
gcacgtacgcgctgtcccccgcgttttaaccgccaaggggattactccct
agtctccaggcacgtgtcagatatatacatcctga
Receptor-Ligand Complex Structure
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PDB7vdv Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		R885 K887 C891 K892 H900 I1039 R1157 W1178 N1179 K1221
Binding residue
(residue number reindexed from 1)		R367 K369 C373 K374 H382 I513 R631 W652 N653 K695
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vdv, PDBe:7vdv, PDBj:7vdv
PDBsum7vdv
PubMed35477757
UniProtP51532|SMCA4_HUMAN Transcription activator BRG1 (Gene Name=SMARCA4)

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