Structure of PDB 7vbb Chain A Binding Site BS01

Receptor Information
>7vbb Chain A (length=1473) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLAL
GPADSKEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCL
NCHMLTCPRAVIHLLLCQLRVLEVGALQAVYELERILNRFIREELEQYTT
EIVQNNLLGSQGAHVKNVCESKSKLIALFWKAHMNAKRCPHCKTGRSVVR
KEHNSKLTITFRGYLTPTSAREHLSALWKNEGFFLNYLFSRFNPSVFFLD
FLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMAQEQS
LIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEKKEGLFRKHM
MGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQ
AVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTQGTKIVCR
HVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYNADFD
GDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGAS
MTTRGCFFTREHYMELVYRGLTDKVGRVKLLSPSILKPFPLWTGKQVVST
LLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMCESQVIIR
EGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFTAYLQ
LYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEAASYD
EVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLHRQFP
ENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEP
YEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSGYLQR
CIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQFPFL
ASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRRGAFL
SYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQKKAA
ACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSELSLD
RLRTLLQLKWQRSLCEPGEAVGLLAAQSIGEPSTQMMNVTLGIPRLREIL
MVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKIDVQEQ
VYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNNKASE
AMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVS
LAHGAVIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYAEVLD
LRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVAD
YMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATMLGSHDELRSP
SACLVVGKVVRGGTGLFELKQPL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vbb Structure of the human RNA polymerase I elongation complex.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		R314 R418 E422 K423 K424 R429 R436 Q553 T982 S983 G986 E1675 T1676
Binding residue
(residue number reindexed from 1)		R264 R336 E340 K341 K342 R347 R354 Q463 T892 S893 G896 E1429 T1430
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:1904750 negative regulation of protein localization to nucleolus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vbb, PDBe:7vbb, PDBj:7vbb
PDBsum7vbb
PubMed34671025
UniProtO95602|RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (Gene Name=POLR1A)

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