Structure of PDB 7v9q Chain A Binding Site BS01

Receptor Information
>7v9q Chain A (length=859) Species: 405948 (Saccharopolyspora erythraea NRRL 2338) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APPNLTREQAEQRAALLEVQSYAIELDLSAGAGGPEVETFGSTTTVRFRS
ATPGAESWIDLVAARVRSAVLNGVELDVSDYDESTGIRLPELAADNELVV
HADCQYTNTGEGLHRFIDPVDGGVYLYSQFETADAKRMFTCFDQPDLKAT
YQITVTAPQDWKVISNAAGEVTDTGEGTRRHVFDTTKPMSTYLVALVAGP
YAEWRDVFPGDDGQDEIPLGIYCRASLAEHLDAERLFIETKQGFGFFHKA
FGVPYPFGKYDQCFVPEFNAGAMENAGCVTFLEDYVFRSRVTGYLYERRS
ETVLHEMAHMWFGDLVTMRWWDDLWLNESFATWASVLAQVGATQYTNAWT
TFASVEKSWAYRQDQLPSTHPVAADIPDLQAVEVNFDGITYAKGASVLKQ
LVAYVGLENFLAGLKVYFDRHAWGNATLDDLLVALEEASGRDLSWWSAQW
LQTTGLNMLRPKLAIDDEGRFTSFSVLQSPARPGAGEHRTHRLAIGIYDD
DPATGELVRTHRVELDVTGERTEVPDLVGVHRGKLVLVNDDDLTYCTMRL
DPQSLATLIDRIADIQESLPRALCWSTAWEMTREAELKARDFVSLVLGSS
PTTGIGAESEIGVVQRVLLQTQTALASYADPAWQPEGWRRFAGRLLELAR
AAEPGSDHQLAFVNSLAGSVLGEEQISAMRGWLDGTAPLEGLTVDTDLRW
GLLQALVAHGAAGEAEIDAELERDQTATGRRRAERARSLIPTPEAKEKAW
QRAVHDDQLPNAISDAIISGFQHPGQRELLASYVRRYFDEIDEVWHRRSS
ERAQPTVIGLFPSWAVDEDTVAVADRWLEGEHAPALRRLVSEGRAGIVRA
LAAREFDRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7v9q Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7v9q Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases.
Resolution2.67 Å
Binding residue
(original residue number in PDB)		H306 H310 E329
Binding residue
(residue number reindexed from 1)		H305 H309 E328
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7v9q, PDBe:7v9q, PDBj:7v9q
PDBsum7v9q
PubMed35513512
UniProtA4F9D7

[Back to BioLiP]