Structure of PDB 7v2z Chain A Binding Site BS01

Receptor Information
>7v2z Chain A (length=440) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CFEPSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRV
VAAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVP
NYNLYIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFP
DSNSPIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLT
KAGKRVIQLSRKTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSR
RCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGC
AETDEDHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTE
QRKTFVELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVP
AEVWTRHGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7v2z Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.
Resolution2.10102 Å
Binding residue
(original residue number in PDB)		T225 R226 T245 C262 A264 T265 D291 S365 V366 S387 R388 T409 D410 I411 P432 L442 D540 R598
Binding residue
(residue number reindexed from 1)		T48 R49 T68 C85 A87 T88 D114 S188 V189 S210 R211 T232 D233 I234 P255 L265 D363 R421
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7v2z, PDBe:7v2z, PDBj:7v2z
PDBsum7v2z
PubMed34904824
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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