Structure of PDB 7uzp Chain A Binding Site BS01

Receptor Information
>7uzp Chain A (length=101) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVMTKEEQIFLLHRAQAQCEKRLKEVLQRPAGRPCLPEWDHILCWPLGAP
GEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKF
L
Ligand information
>7uzp Chain B (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YQDLRRRFFKHHLKAEKHTAEI
Receptor-Ligand Complex Structure
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PDB7uzp Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		V31 M32 K34 L41 D69 I71 Y92 D93 V113 R118 T119 W120 A121 Y123 F129 L130
Binding residue
(residue number reindexed from 1)		V2 M3 K5 L12 D40 I42 Y63 D64 V84 R89 T90 W91 A92 Y94 F100 L101
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:7uzp, PDBe:7uzp, PDBj:7uzp
PDBsum7uzp
PubMed36409914
UniProtQ03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)

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