Structure of PDB 7uy5 Chain A Binding Site BS01

Receptor Information
>7uy5 Chain A (length=1012) Species: 5911 (Tetrahymena thermophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFL
TTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQI
GTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTK
VEQNGYLQVAGVCLNQYFSENQYIYPEIQRSQIFYCNHMGREPGVFKSSF
FNYSEPQTIIKKTLLKEYQSKNFSCQEERDLFLEFTEKIVQNFHNINFNY
LLKKFCKLPENYQSLKSQVKQIVQSENKANQQSCENLFNSLYDTEISYKQ
ITNFLRQIIQNCVPNQLLGKKNFKVFLEKLYEFVQMKRFENQKVLDYICF
MDVFDVEWFVDLKNQKFTQKRKYISDKRKILGDLIVFIINKIVIPVLRYN
FYITEKHKEGSQIFYYRKPIWKLVSKLTIVKLEEENLEKVEEKLIPEDSF
QKYPQGKLRIIPKKGSFRPIMTFLRKDKQKNIKLNLNQILMDSQLVFRNL
KDMLGQKIGYSVFDNKQISEKFAQFIEKWKNKGRPQLYYVTLDIKKCYDS
IDQMKLLNFFNQSDLIQDTYFINKYLLFQRNKRPLLQIMDNINFPYYFNL
KERQIAYSLYDDDDQILQKGFKEIQSDDRPFIVINQDKPRCITKDIIHNH
LKHISQYNVISFNKVKFRQKRGIPQGLNISGVLCSFYFGKLEEEYTQFLK
NAEQVNGSINLLMRLTDDYLFISDSQQNALNLIVQLQNCANNNGFMFNDQ
KITTNFQFPQEDYNLEHFKISVQNECQWIGKSIDMNTLEIKSIQKQTQQE
INQTINVAISIKNLKSQLKNKLRSLFLNQLIDYFNPNINSFEGLCRQLYH
HSKATVMKFYPFMTKLFQIDLKKSKQYSVQYGKENTNENFLKDILYYTVE
DVCKILCYLQFEDEINSNIKEIFKNLYSWIMWDIIVSYLKKKKQFKGYLN
KLLQKIRKSRFFYLKEGCKSLQLILSQQKYQLNKKELEAIEFIDLNNLIQ
DIKTLIPKISAK
Ligand information
>7uy5 Chain B (length=156) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccgcuuaauucauucagaucuguaauagaacugucauucaaccccaaaa
aucuagugcugauauaaccuucaccaauuagguucaaauaagugguaaug
cgggacaaaagacuaucgacauuugauacacuauuuaucaauggaugucu
uauuuu
<<<<<..........<<<.<<<<...>>>>.>>>................
...............<<<<<..((((.((>>>>>.....)).))))...>
>>>>..<..<<<<.<<<...<.<<<<<<.......>>>>>>>.>>>>>>>
>.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uy5 Structure of Tetrahymena telomerase-bound CST with polymerase alpha-primase.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		K11 H234 M235 R237 F242 K243 S244 N324 Y325 K328 K329 K332 L333 Y337 Q382 L420 D421 C424 V428 Q444 K445 R446 K447 I449 S450 R453 R473 K532 R534 T547 D552 K553 R658 P693 Y694 N697 K762 G774 L775 N776 I909 K913 S914 K917 I967 S972 K973 V977 K990 Y994 Y995 E1019 K1038 K1040 K1041 K1044 Q1052 K1056 S1057 F1059 F1060 Y1061 K1063 K1101
Binding residue
(residue number reindexed from 1)		K1 H188 M189 R191 F196 K197 S198 N249 Y250 K253 K254 K257 L258 Y262 Q307 L345 D346 C349 V353 Q369 K370 R371 K372 I374 S375 R378 R398 K457 R459 T472 D477 K478 R583 P595 Y596 N599 K664 G676 L677 N678 I811 K815 S816 K819 I869 S874 K875 V879 K892 Y896 Y897 E921 K940 K942 K943 K946 Q954 K958 S959 F961 F962 Y963 K965 K1003
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003720 telomerase activity
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0042162 telomeric DNA binding
GO:0046872 metal ion binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0007004 telomere maintenance via telomerase
Cellular Component
GO:0000333 telomerase catalytic core complex
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005697 telomerase holoenzyme complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uy5, PDBe:7uy5, PDBj:7uy5
PDBsum7uy5
PubMed35831498
UniProtO77448|TERT_TETTS Telomerase reverse transcriptase (Gene Name=TERT)

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