Structure of PDB 7uxw Chain A Binding Site BS01
Receptor Information
>7uxw Chain A (length=346) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFGPLSHFLEG
VLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEIS
VDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGE
TWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKE
FQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLR
TEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
Ligand information
>7uxw Chain E (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uxw
ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination
Resolution
2.57 Å
Binding residue
(original residue number in PDB)
R158 L159 R161 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R11 L12 R14 H55 E225 K234
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uxw
,
PDBe:7uxw
,
PDBj:7uxw
PDBsum
7uxw
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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