Structure of PDB 7uvp Chain A Binding Site BS01

Receptor Information
>7uvp Chain A (length=718) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVYQTNEIKNIALLGSSGSGKTTLVEAMLFESGVIKRRGSVAAKNTVSD
YFPVEQEYGYSVFSTVLHVEWNNKKLNIIDCPGSDDFVGSTVTALNVTDT
AIILLNGQYGVEVGTQNHFRYTEKLNKPVIFLVNQLDNEKCDYDNILEQL
KEAYGSKVVPIQYPIATGPGFNALIDVLLMKKYSWKPEGGAPVIEDIPAE
EMDKAMEMHKALVEAAAENDEGLMEKFFEQDSLTEDEMREGIRKGLIARG
MFPVFCVCGGKDMGVRRLMEFLGNVVPFVSEMPKVENTDGKEVAPDVNGP
ESLYFFKTSVEPHIGEVSYFKVMSGKVREGDDLLNADRGSKERIAQIYVV
AGGNRVKVEELQAGDIGAAVKLKDVKTGNTLNGKDCDYKFNFIKYPNSKY
SRAIKPVNEADVEKMMTILNRMREEDPTWVIEQSKELKQTLVHGQGEFHL
RTLKWRLENNEKLQVKFEEPKIPYRETITKAARADYRHKKQSGGAGQFGE
VHLIVEPYKEGMPVPDTYKFNGQEFKITVRGTEEIPLEWGGKLVFINSIV
GGSIDARFLPAIMKGIMSRLEQGPLTGSYARDVRVIVYDGKMHPVDSNEI
SFMLAGRNAFSEAFKNAGPKILEPIYDVEVFVPSDRMGDVMGDLQGRRAM
IMGMSSEKGFEKLVAKVPLKEMSSYSTALSSLTGGRASFIMKFASYELVP
TDVQDKLIKDFEAKQTEE
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain7uvp Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uvp Cryo-EM structure of the ribosome-bound Bacteroides thetaiotaomicron EF-G2
Resolution3.7 Å
Binding residue
(original residue number in PDB)		S18 G19 G21 K22 T23 T24 V42 Y60 S61 P82 Q135 D137 N138 G260
Binding residue
(residue number reindexed from 1)		S18 G19 G21 K22 T23 T24 V42 Y60 S61 P82 Q135 D137 N138 G260
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006414 translational elongation
GO:0032790 ribosome disassembly

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7uvp, PDBe:7uvp, PDBj:7uvp
PDBsum7uvp
PubMed
UniProtQ8A5S1

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