Structure of PDB 7uva Chain A Binding Site BS01
Receptor Information
>7uva Chain A (length=329) Species:
10090
(Mus musculus) [
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RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
>7uva Chain C (length=11) Species:
9606
(Homo sapiens) [
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APATGGVCKPH
Receptor-Ligand Complex Structure
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PDB
7uva
Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Resolution
1.98 Å
Binding residue
(original residue number in PDB)
M111 Q116 I144 S145 N186 A187 I188 Y199 T209 F215 K323 F324 R325
Binding residue
(residue number reindexed from 1)
M76 Q81 I109 S110 N151 A152 I153 Y164 T174 F180 K288 F289 R290
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:7uva
,
PDBe:7uva
,
PDBj:7uva
PDBsum
7uva
PubMed
36797403
UniProt
P59997
|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)
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