Structure of PDB 7uuz Chain A Binding Site BS01

Receptor Information
>7uuz Chain A (length=501) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATFGAWDYGVFATMLLVSTGIGLWVGLALAAVPVGLSLAASFMSAVQVLG
VPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRF
SRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIIC
TLYTTVGGWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQQHSRIN
LMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKL
ALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVL
DIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAP
RKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGA
FTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSA
AGPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLW
W
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain7uuz Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7uuz Structural insights into the mechanism of the sodium/iodide symporter.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Q72 Y144 S416 F417
Binding residue
(residue number reindexed from 1)		Q47 Y119 S386 F387
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008507 sodium:iodide symporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015293 symporter activity
GO:0015373 monoatomic anion:sodium symporter activity
GO:0022857 transmembrane transporter activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006590 thyroid hormone generation
GO:0006814 sodium ion transport
GO:0015705 iodide transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0098656 monoatomic anion transmembrane transport
GO:1904200 iodide transmembrane transport
GO:1904322 cellular response to forskolin
GO:1904401 cellular response to Thyroid stimulating hormone
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uuz, PDBe:7uuz, PDBj:7uuz
PDBsum7uuz
PubMed36517601
UniProtQ63008|SC5A5_RAT Sodium/iodide cotransporter (Gene Name=Slc5a5)

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