Structure of PDB 7uu4 Chain A Binding Site BS01

Receptor Information

>7uu4 Chain A (length=373) Species: 9544 (Macaca mulatta)

QIRNMVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKI
FQGKVYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANS
VATFLAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEF
QDCWNKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFN
NKPWVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRH
AALCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLC
IFAARIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPF
QPWDGLDEHSQALSGRLRAILQN

Ligand information

>7uu4 Chain R (length=6)

uaauuu

......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7uu4 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): R24 I26 L27 S28 V58 Y59 P60 A62 H65 W94 R99 Y124 Y125 F126 W127 Y131 F268 K270
• Binding residue (residue number reindexed from 1): R21 I23 L24 S25 V55 Y56 P57 A59 H62 W91 R96 Y121 Y122 F123 W124 Y128 F261 K263

Enzymatic activity

• Enzyme Commision number: 3.5.4.-
  3.5.4.38: single-stranded DNA cytosine deaminase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004126 cytidine deaminase activity
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009972 cytidine deamination
• GO:0010526 retrotransposon silencing
• GO:0045087 innate immune response
• GO:0051607 defense response to virus
• GO:0070383 DNA cytosine deamination

Cellular Component

• GO:0000932 P-body
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uu4, PDBe:7uu4, PDBj:7uu4
• PDBsum: 7uu4
• PubMed: 36470880
• UniProt: M1GSK9