Structure of PDB 7uu3 Chain A Binding Site BS01

Receptor Information

>7uu3 Chain A (length=369) Species: 9544 (Macaca mulatta)

MVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKIFQGK
VYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVATF
LAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEFQDCW
NKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKPW
VSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAALC
FLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAA
RIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWD
GLDEHSQALSGRLRAILQN

Ligand information

>7uu3 Chain C (length=11)

cccacgggaau

...........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7uu3 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
• Resolution: 3.099 Å
• Binding residue (original residue number in PDB): R24 I26 L27 S28 Y59 W94 Y124 Y125 W127 N176 K270
• Binding residue (residue number reindexed from 1): R17 I19 L20 S21 Y52 W87 Y117 Y118 W120 N165 K259

Enzymatic activity

• Enzyme Commision number: 3.5.4.-
  3.5.4.38: single-stranded DNA cytosine deaminase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004126 cytidine deaminase activity
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009972 cytidine deamination
• GO:0010526 retrotransposon silencing
• GO:0045087 innate immune response
• GO:0051607 defense response to virus
• GO:0070383 DNA cytosine deamination

Cellular Component

• GO:0000932 P-body
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7uu3, PDBe:7uu3, PDBj:7uu3
• PDBsum: 7uu3
• PubMed: 36470880
• UniProt: M1GSK9