Structure of PDB 7usw Chain A Binding Site BS01

Receptor Information
>7usw Chain A (length=608) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHESKVSRS
HLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFL
RWIVFVNIMITLIALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVH
ADELAVVWHYDGYLRYSPLFYGYYSDDPFLGNKIKYALPLAYFMVTLTIF
AYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIGNSETASN
TVMAVVIKLRESIADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCI
IFAVQKSQVQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTA
LRAHLGRVLILYTVNYITLIFALFEKMTALRDRVNNDICWETIIGQEIVK
LVTMDLIFTILSILVIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAEN
VLHIINNQGMIWLGLFFAPLLPAINNIKLIILMYIRGWAVMTCNVPAREI
FRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARYQHFYTV
VTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREA
NTDLQAQL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7usw Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7usw Structures of the TMC-1 complex illuminate mechanosensory transduction.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D695 F723
Binding residue
(residue number reindexed from 1)		D417 F445
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005272 sodium channel activity
GO:0008381 mechanosensitive monoatomic ion channel activity
Biological Process
GO:0007606 sensory perception of chemical stimulus
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050906 detection of stimulus involved in sensory perception
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7usw, PDBe:7usw, PDBj:7usw
PDBsum7usw
PubMed36224384
UniProtD3KZG3|TMC1_CAEEL Transmembrane channel-like protein 1 (Gene Name=tmc-1)

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